Borreliosis is caused by a bacterium (a spirochaete) that normally enters the body through a tick bite. In most cases, the infection progresses without severe symptoms and is controlled and finally eliminated by the immune system. However, if the immune system’s protection is not sufficient, the infection may become chronic (e.g. it will affect the joints). Currently, there is no available vaccine for borreliosis. Therefore, if a patient notices a tick bite and develops symptoms of borreliosis, a diagnostic procedure should be initiated.
The most important pathogenic species causing borreliosis are Borrelia burgdorferi, Borrelia garinii and Borellia afzelii, which are distantly related to the syphilis-causing pathogen Treponema pallidum.
In addition to borreliosis, a tick bite can also transmit other pathogenic agents (e.g. Rickettsia, Babesia and ehrlichiosis).
|LymeSpot Revised||CPDA tubes|
|LymeSpot Revised or Borrelia and Chlamydia pneumoniae||CPDA tubes|
|Borrelia EliSpot||CPDA tubes|
|CD3-/CD57+ cells||Heparin + EDTA tubes|
|Borrelia IgG and IgM-EIA||Serum tubes|
|Borrelia IgG and IgM-Blot||Serum tubes|
|DNA-PCR Borrelia, after positiv result
→ differentiation of species Borrelia-DNA PCR
|Borrelia miyamotoi EliSpot||CPDA tubes|
|Immun status||Heparin + EDTA tubes|